Same thing happened to me. I had a radical prostatectomy in 2005 (Gleason 6) , and thought that took care of my problem. Then, ten years later, a blood test as part of my annual physical revealed an elevated PSA level. A scan showed cancer cells near my bladder. I underwent cyberknife surgery which lowered my PSA level to near zero, but then six months later the level began to rise. Since then we've been playing whack-a-mole with the cancer cells, which now are in my lymph nodes. After four rounds of radiation therapy I've been told that further radiation might cause tissue damage, so I am now in what is called systematic therapy, which uses two medications, a Lupron injection every three months and a daily Erleada pill. I'll be checking in with my oncologist at Georgetown University Hospital next week to assess the efficacy of this protocol. More to come.