Doc tested me for everything he could think of; bacterias, fungus, parasites, CT scanned my abdomen, and he said I'm all normal. Even checked pancreas performance and that's just super also. I've had constipation with somebody adult life but within the last 18 months to 2 years I started not being able to eat a lot because I would feel terrible, not even nauseated just terrible, so he's trying to figure out what was going on there but I'm just glad that Linzess works....