I've been constipated for maybe 40 years. Since I'm overall healthy most doctors would just tell me to eat healthy, eat more fiber, take some metamucil, and drink plenty of water. Well it's all meaningless if there's something really wrong so I finally got a doctor to listen to me any prescribed Linzess. I've been taking the 290 for about 8 months now. I don't have to go to work anymore so I don't mind going to the bathroom for a couple of hours in the morning. I've tried different times what I've concluded now is that I wake up and take it at 03:30 so that when I get up a couple of hours later I am processing. The doctor seems to think I have chronic constipation with no known cause, and/or IBS, but whatever it is I am really glad after decades to not be plugged up everyday. I had to look up that "chronic constipation with no known cause" cuz it didn't sound like something real - but I reckon it is. Fascinating. Ask your doctor about Linzess - it's ridiculously expensive so I'm lucky to have good coverage but it's worth asking