← Return to Bone turnover markers (CTX and P1NP): do you have a baseline?

Discussion
Comment receiving replies
@loriesco

Hi @gently, I am a little confused. And, maybe my post wasn't clear enough. It had to be read in contect to the previous message. I was responding to the concern about having baselines for the P1NP and CTX. My doctor didn't offer the baseline but gave it to me when I asked. After i had done more reading I remember reading how it wasn't critical or definitive. So it made sense why my very serious doctor wasn't concerned about doing them. My surgery was in 2023 and my DEXAs never indicated anything more than osteopenia. In fact - I had come out of it. So the paper-thin cervical vertebrates were a shock to everyone. My bone marker tests were done in 2024 - all of them - the new DEXA with the TBS, the two CTX and P1NPs which looked good after starting the bone meds and things did what they should have over the 6 month interval.
I haven't done anything yet in 2025. So I was confused by "Bone markers in 25 indicate even greater bone loss" . I did one round of Reclast and I'm on the TYMLOS and the CTX and P1NP did what they statistically were supposed to do. (I don't remember off hand what that was).
But my visits to the Orthopedic Surgeon continue to get me summaries of "demineralized" bones along with the MRI reads. So I'll just stay with it all!

Jump to this post


Replies to "Hi @gently, I am a little confused. And, maybe my post wasn't clear enough. It had..."

loriesco the summaries of demineralized bones sounds very interesting. Can you tell me more. Do these summaries include, well, which bones. Could they have done this for your neck before the bone-crumbling surgery. It seems like this is a new technique with MRI involving different sequences. I'd be curious about what type of reading you get. Numbers?
Information about bone matrix before surgery is so crucial.
I was responding to the information that on the anabolics P1NP numbers lessen. Which they do after you've been on it for while, plateau at 6 to 12 months and then lessen.
I love the way you "paint the street," with your responses.
How often do you get the summaries.