"Systemic hormone replacement therapy (HRT) has been shown to positively influence lipid profiles, typically increasing high-density lipoprotein (HDL) cholesterol and decreasing low-density lipoprotein (LDL) cholesterol.

In response to your previous mention of aspirin use for cardiovascular health:

While aspirin is commonly used for secondary prevention of cardiovascular events, there are safer alternative approaches. Tadalafil, initially developed for coronary artery disease (CAD), has demonstrated pleiotropic effects, including potential benefits for cardiovascular, cerebrovascular, and bone health. Some studies suggest it may reduce certain cardiovascular events by approximately 30%. Although originally indicated for CAD, its use has been hijacked. It's worth noting that tadalafil (Cialis) is available over-the-counter in the United Kingdom.