I had the same issue when I started Arikayce. I'd have to stop for a week then resume. I'd be okay for awhile, then I'd totally lose my voice. So frustrating! My doctor was worried that I'd become resistant to the Arikayce if I stopped so often so he reduced the dose to every other day. I'd get hoarse occasionally but I never truly lose my voice after that. I'm not sure your doctor would consider doing that but it wouldn't hurt to ask!