There's really little reason for most people to still be going through the discomfort of ADT injections any more, except that some insurers don't want to pay the extra $$$ for Orgovyx

(Exceptions: prostate-cancer patients with dementia or other cognitive disorders, where it might be beneficial for the doctor to give the injection to make sure the patient is getting their ADT, and the small number of patients who don't respond to GnRH receptor antagonists.)

So I have a question: I watched a video produced by Dr. Eugene Kwon at the Prostate Cancer Research Institute discussing hardening of resistance by long-term use of suppressive forms of therapy. "We strongly prefer taxane-based chemotherapy for initial treatment after a patient has failed both hormone therapy and an ARPI agent." Thoughts?