For my constipation, specifically, I take one Linzess 290 mcg (prescription), 2 gelcaps of stool softener [Bisocodyl] (otc) and one extra-strength gas-X with breakfast. At lunch, I take one more stool softener. If I go for more than 5 days without a b.m., I force myself to have diarreah by taking 10 mg Colace (otc) with my other breakfast meds. This causes about 6 days of multiple but quick attacks of diarreah, but not enough to empty out. If it doesn't work, I up it to 1 Colace at Breakfast and 1 at bedtime. And I wear a pull-up, and put a pad on the mattress. Once I've suffered thru the 6 days, I drop the colace, and my body will switch back to my happy normal of 3 days constipation, 3 days diarreah, until everything stops up again. Don't give up! And your GI has, I hope, sent you for a Motility test???? Good luck.