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Bone turnover markers (CTX and P1NP): do you have a baseline?
Osteoporosis & Bone Health | Last Active: Mar 24 11:26am | Replies (214)Comment receiving replies
Loriesco, I have a different take on bone markers. And you may be correct.
Bone markers might have helped identify the bone fragility in the cervical neck and you could have been given protective medication in advance of the surgery.
As it was your bone markers in 24 indicate bone loss.
Bone markers in 25 indicate even greater bone loss.
If you took a bisphosphonate your CTX would drop at least 20% P1NP might drop slightly
Most importantly, if you take the coveted Tymlos or Forteo your P1NP WON'T DROP . If the drug is working you'll probably increase P1NP the usual 100% or more.
Since the 1990s bone markers have become reliable with new agents and some standardization.
It seems in your case bone markers would have been more reliable than dxa.
I await your response in good faith.
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Hi @gently, I am a little confused. And, maybe my post wasn't clear enough. It had to be read in contect to the previous message. I was responding to the concern about having baselines for the P1NP and CTX. My doctor didn't offer the baseline but gave it to me when I asked. After i had done more reading I remember reading how it wasn't critical or definitive. So it made sense why my very serious doctor wasn't concerned about doing them. My surgery was in 2023 and my DEXAs never indicated anything more than osteopenia. In fact - I had come out of it. So the paper-thin cervical vertebrates were a shock to everyone. My bone marker tests were done in 2024 - all of them - the new DEXA with the TBS, the two CTX and P1NPs which looked good after starting the bone meds and things did what they should have over the 6 month interval.
I haven't done anything yet in 2025. So I was confused by "Bone markers in 25 indicate even greater bone loss" . I did one round of Reclast and I'm on the TYMLOS and the CTX and P1NP did what they statistically were supposed to do. (I don't remember off hand what that was).
But my visits to the Orthopedic Surgeon continue to get me summaries of "demineralized" bones along with the MRI reads. So I'll just stay with it all!