I've learned that inflammatory diseases have ups and downs and the downs are when we feel completely bewildered and defeated. It's helped me, and so I remind you, to remember this is also part of the disease process. Your doctors are working on this, and while getting a Mayo opinion is always worthwhile - and it's just so healing to be the Mayo environment - there's no guarantee you'd be better off in the end. Keep working with your doctors...maybe consider another option for 2nd opinion, and above all - nurture yourself!! Today is a bad day. Hope for a better tomorrow because it is possible.