I developed PFS (post finasteride syndrome) from taking finasteride for hair loss for about 24 months. I got off the drug over 3 years ago and I still have permanent sexual dysfunction, genital numbness, anhedonia, no motivation, executive function, extreme brain fog and memory problems. I am an entirely different person than i used to be. Absolutely devastating, I also became infertile from that drug and I am only 32 and unmarried. This started when I was 28. I am also a pharmacist now (I was about to start school when I developed side effects that never went away. I am good friends with an anesthesiologist who developed this same permanent condition just from taking saw palmetto for a few months. He has been suffering for almost 5 years.

Also, in all of the research I have done in the last several years and all the treatments I have tried from
The best doctors, I got very specific pelvic floor physical therapy and my therapist eventually said he sees nothing to treat. And basically told me I never had a hypertonic pelvic floor upon all examinations. The reason for the pelvic floor dysfunction is because these tissues are rich in androgen receptors and in the absence of DHT, the receptors can compensate via severe mechanistic upregulation and can remain chronically overexpressed, stuck in a broken feedback loop due to the chemical assault they endured in the the face of extreme and unnatural androgen deprivation. The lack of DHT-Androgen receptor binding can disrupt normal gene transcription thereby inducing epigenetic changes through gene methylation for genes that encode for proper Androgen receptors function as well as proper neurosteroid production. Conveniently, the drug insert omits this information, along with proper informed consent opportunity.