← Return to Bone turnover markers (CTX and P1NP): do you have a baseline?

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@loriesco

my thoughts is do more research and you will find out why these markers have to be taken with a grain of salt in the short haul. My specialist only did it because I complained and wanted baselines. Then I read the research, and it is indeed unreliable by themselves. It is just a tool from year to year. Looked at over a few years. You didn't say the break between your testing.
Do a DEXA WITH A TBS SCORE a year apart and see how that looks. I can tell you my regular DEXAS were okay over 20 years with the last one saying I had come out of ostopenia even! Then I had cervical surgery and my C5 fell apart in their hands! I asked the surgeon how it could be and he explained they are standardized tests, and as well, your body bones have different density requirements. Nobody ever did a DEXA on my neck! So don't worry!

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Replies to "my thoughts is do more research and you will find out why these markers have to..."

Loriesco, I have a different take on bone markers. And you may be correct.
Bone markers might have helped identify the bone fragility in the cervical neck and you could have been given protective medication in advance of the surgery.
As it was your bone markers in 24 indicate bone loss.
Bone markers in 25 indicate even greater bone loss.
If you took a bisphosphonate your CTX would drop at least 20% P1NP might drop slightly
Most importantly, if you take the coveted Tymlos or Forteo your P1NP WON'T DROP . If the drug is working you'll probably increase P1NP the usual 100% or more.
Since the 1990s bone markers have become reliable with new agents and some standardization.
It seems in your case bone markers would have been more reliable than dxa.
I await your response in good faith.