I tried Tintellix after a long relationship with Paxil, among others. Trintillix was a completely horrible experience for me. After a few frightening months, my psychiatrist changed me over to Prozac, a completely different generation from Trintillix, and that was 10 months ago. I also take Clonazepam, and have taken a therapeutic dose of 1mg twice daily. I have dysthymia, so depression is a constant background, but I function normally, or at least more normally. Sadly, medication is a roll of the dice. Make eye contact with your doctor. Put your cards face up on the table. Your doctor is on your payroll..