I don't know if it's exercise, genetics or luck but I've been on Orgovyx for 7 weeks with almost zero side effects. Most noticeable is loss of libido, but since I'm single right now it doesn't really matter. I just started getting a few mild hot flashes at night, but I got them occasionally before the drugs so don't know if that is the cause. I'm 65 and have been running and lifting for years, so just continued my routine, even increased the lifting. I'd say I'm a bit slower than I was before ADT, but not significantly, but I'm not really pushing it. Just registered for a marathon in October so will be training as much as I can while going through RT, which starts in 2-3 weeks.