Connect
PSA Spike after Triplet Therapy - Anxious
Good afternoon everyone,
I just got a call from the oncologist on my dad's recent PSA test and was shocked. It went up from 0.16 in October 2024 to 3.43 in Feburary 2025. He was diagnosed de novo in June 2023 (stage IV, gleason 9, mets to lymph nodes and spine), started hormone therapy immediately, then commenced taxotere chemo and darolutamide in Aug 2023. He has been on darolutamide since then and his PSA dropped from 800 to its lowest which was 0.1. I am trying hard not to panic but I was not expecting darolutamide to start failing only 18 months after starting. We have a meeting with the oncologist on March 5th which I am trying to get moved forward; however, I really would appreciate any information anyone has of similar situations or other treatment options my dad could try from here. I know that one PSA rise shouldn't incite panic as it is a trend that matters more; however, a spike of 21x is definitely leaving me feeling like a bit of a punch to the gut.
Like
Helpful
HugInterested in more discussions like this? Go to the Prostate Cancer Support Group.
Connect
My original CT and bone scan back in 2022 showed it was stage 4. It in my spine T12, pectoral right bone and prostate. I just completed an PSMA Pet scan a few weeks ago. It's still only in those areas , not spreading thank God.
-
Like -
Helpful -
Hug
1 ReactionYes I feel it was gradual over the last year. Aside from the meds side effects I feel great.
If it is only in bone radium 223 Is used to try to attack bone metastasis. You might ask your doctor if that’s possible to do with your condition.
That's really good news that you are symptom free and that the PSA rise is gradual. Unfortunately my dad is struggling with symptoms at the moment so I am hoping more treatment will relieve his backpain.
After our appointment with my dad's MO the scans did confirm progression in his bones so he is restarting chemo (Jevtana/cabazitaxel) on April 1st. The MO is also starting him on Xgeva. I was hoping Pluvicto might be an option but MO said we should make chemo a priority before considering that. Praying hard that chemo is the best choice for now and mostly that it relieves his symptoms. When dad got his first round of chemo with docetaxel it really did help his back pain so fingers crossed.