I agree with Sandi here. I tried taking 37.5 every other day and I felt awful. Dizzy, emotional, off balance physically, with a ton of brain fog. I learned a ton from being on this blog and I've since gone back up to 75mgs to stabalize here. Once I've done that for 3-4 weeks I'm going to pull those stupid little pills apart and take out 5-7 beads and stay at that dose for a few weeks. Then do it all again until I'm down to a few beads, then none. Doing the dramatic drops that the doctor recommended felt absolutely horrible. Please trust the folks on this blog who've done this. Slow is definitely your friend when it comes to Effexor!!