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Gleason 8 diagnosis at 51: Likely opting for surgery

Prostate Cancer | Last Active: 21 hours ago | Replies (61)
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@topf

I am looking into doing a second opinion on my PSMA. I had my second biopsy opinion done by JHU, they found the PNI in the discontinuous 3+3 core. They also found much larger volume in thee of the. ores than the first opinion.

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Replies to "I am looking into doing a second opinion on my PSMA. I had my second biopsy..."
brianjarvis | @brianjarvis | 1 day ago

Either a 2nd opinion on the PSMA PET scan or —>
Note that up to 15% of prostate cancers may be PSMA-negative (or PSMA-naive), and not express any (or much) PSMA, such that a PSMA PET scan won’t even see them - even though you know something is wrong due to the elevated PSA or biopsy results.
Ask your doctor about using an older type of PET scan (one that ordinarily PSMA PET is much better than - when there is PSMA expression), one that isn’t dependent on PSMA - like the older Axumin PET or FDG PET scans - which might be able to detect the location of the recurrence that is causing your Gleason? (Mayo Clinic often uses the older C11 Choline PET scan for this purpose.)

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