While there are 3 standard medications, I would know which is being considered standard. I know that sounds odd but my mom ( I was her caretaker for 5 years) had tried more than just 3. So which 3 are they going to try you on? Azithromycin and Ethambutol didn't cause issues with my mom. Rifampin made her severely nauseous and she couldn't keep food down at all. Also, Rifampin and Rifabutin will cause your urine, stools ,etc to be red(dish) so do not be alarmed. Arikayce nebulizer treatments almost killed my mom as they caused fluid in her lungs and she felt like she was drowning after each use ( I have already many that it's helped though). The Amacaycin shots made her very sick and they hurt her but they helped her after a bit.