My first infusion I had flu like symptoms. They passed in about 6 hours. I had no adverse reactions with my second infusion. After my second infusion, I had a DEXA scan about 7 months later, my numbers improved. Currently I am on a break from Reclast due to the improvement, and also my bone markers from bloodwork. I have more bloodwork scheduled for May. I’ll see what happens after that. Hope this helps.