I am on the combination now. Can't speak for you only for myself. but been on Prozac for over twenty years, and up until the Holidays (got covid) and knocked me for a loop. Was placed on Remeron Feb 28th. 15 mg before bedtime (1/2 tab) it makes me jittery and sleepy most of the following day. Wears off later in the evening slowly. I don't have a appetite, it is suppose to help(not yet) Good Luck