I was really sick when I first started Captem. I experienced side effects of nausea, vomiting... you will be given something for the nausea and vomiting to take before taking the Temozolomide, overall body aches and pains, mouth sores, neuropathy, and fatigue. I didn't get everything all of the time, but I did experience most of them eventually. My body has adapted much better over time. I no longer take support meds like gabapentin for nerve pain or motion sickness patches for nausea. It does take some getting used to but I am alive. I shouldn't be. If you have any other questions, just let me know.