Just to add: this is the way we discover side effects that are not common, but still real and important. If we find that our PN correlates with dosage changes of a drug, or with starting and stopping a drug, we get to contribute to science and drug development if we report this to the FDA -- they won't explore it if no one knows it is happening.

And let's face it, these drugs are sledge hammers. GLP-1 serves tons of purposes in the body, and therefore positive and negative side effects are inevitable, many of which will either not emerge in clinical trials, or are not being looked for or lost in the noise.

So bravo to everyone for noticing these correlations, and please report your personal experience to the FDA.

In my case, I'm no longer convinced that the source of my problem is the GLP-1 RA -- pretty sure it was a coincidence of timing, since it doesn't seem to change with dosage, and avoiding B6 supplementation seems to have correlated more strongly. Having said that, I have not tried stopping the GLP-1 RA altogether. That would be the real test, but the PN is not bad enough to drive me there.