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← Return to Positive Evenity results
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daisy17, do you remember where you read that Evenity doesn't provide much protection against fracture. Outside of the other cautions, I'm wondering about the bone--the quality of the bone. My understanding is that it is modeled bone rather than remodeled. Meaning that it doesn't allow for clearing away old bone, simply lays down new bone on top of the old. Sort of like replastering or repainting your house without removing the broken, damaged material underneath. In cartoons showing the bone laid down, there isn't any articulation. It is just solid bone. And easy to see why bone mineral density would be increased without reduction of fracture risk. I don't know, but it makes me wonder.
Replies to "daisy17, do you remember where you read that Evenity doesn't provide much protection against fracture. Outside..."
Evenity builds bone. I do not understand that it also somehow stops the osteoclasts from breaking bone down. And this is also the 1st time I have heard anything about the terms 'modeled' v. 'remodeled.'
My understanding is that it is the bisphosphonates that stop the osteroclasts from clearing away old bone so that when the osteoblasts----the bone builders---do their job, it is on top of old bone. Get an increase in density but perhaps not a good quality.
Do you have any links for the information that Evenity stops/inhibits osteoclastic action of breaking down old bone?
I think I remember reading somewhere that Evenity is a bone builder in its first 6 months and perhaps a bisphosphonate in its second 6 months. Wish Windyshores was still here....think she understood this very well.
This is from Amgen's literature: “Bone mineral density (BMD) results do not imply fracture risk reduction. Women receiving Evenity had fewer new spinal fractures (0.5%) than women receiving placebo (1.8%) at 12 months. Reductions in fractures other than the spine were not significant at 12 months.” So Evenity offers a 1.3% vertebral fracture prevention benefit.
Since Evenity is so new, there aren't longer term studies on its fracture reduction percentages. I don't know if Amgen is doing any studies on this since Evenity was made available to patients. Thanks for your insight.
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I have exactly the same question.
After finishing 12 Evenity injections, I had a DEXA to see what had changed--same machine, no changes in its calibration or software, same technician. DEXA showed all areas returned to osteopenia range, and the prescribing endo complimented the treatment, saying I was no longer in osteoporosis.
I then went to a REMS provider, and had a scan there. Results show that I am still in the "red zone" for fracture in both femoral necks, hips in general.
I asked the test technician, a PhD in pharmacology, the same question you just asked.
He replied that he could never understand the logic behind Eventiy-->Reclast, for the very reason you bring up.