I would think it would depend on what cocktail you're having for your chemo. I'm TNBC BRCA2+ and I had my husband take me to the first treatment because they gave me something like a Benadryl and needed to see if it made me too drowsy to drive home - it didn't so I drove myself to all my subsequent treatments and I continued working throughout my chemo treatments. I did 4 treatments of Adriamycin – IV push – 90 mg/Cytoxan – IV drip – 900 mg and 12 weekly treatments of Taxol – IV drip – 110 mg. I was 69 at the time. I was fortunate my drive to treatments was about 20-30 minutes. I took a treatment bag with a drink to help me stay hydrated, ginger candy (in case I got nauseous), other snacks, knitting, iPod and reading material because I never knew how long I would stay focused. I also had a mediport which was convenient - it allowed my hands to remain free for whatever I chose to do during treatment. I was able to arrange my treatments on a Thursday afternoon so if I started to tire on Friday I knew Saturday was around the corner. Saturday was a lazy day and I started to bounce back on Sunday so I could start the next week. I will say I think I weathered my treatments exceptionally well.