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Gleason 8 diagnosis at 51: Likely opting for surgery
Prostate Cancer | Last Active: 7 minutes ago | Replies (27)Comment receiving replies
I am of course not bsnking on a downgrade, but it is an additional source of diceyness in the decision.
And there are several studies that look at doengrades and upgrades post-pathology. And with 4+4 they find 40-50% probability of a downgrade and something like 10% of an upgrade. On the other hand, lower grade cancers at biopsy have a higher chance of being upgraded.
Two things are at play here, I believe. Firstly, regression to mean: Any estimate that is to either extreme is likely to be an over or underestimate. Secondly, you use a different metric. The max of a small, untepresentative sample at biopsy and the median at pathology.
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The moral of the story is that this is not an exact science and you might even be second guessing whatever decision you make for many years afterwards. I see it here frequently.
Be your own advocate because whatever decision that you make that you feel is right for you is right for you. Commit to the course and don't look back because you can't change your decision once you've done whatever "the thing" is that you decide.