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Positive Evenity results

Osteoporosis & Bone Health | Last Active: Mar 16 2:26pm | Replies (109)

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@daisy17

I am also curious about the quality of the bone produced by Evenity, for two reasons: 1. You must take another drug, like a bisphosphonate, after Evenity or you lose all your gains. I am curious as to why? That doesn't sound like typical bone to me. I've tried to research this on-line but can't find anything about this. 2. I've read that Evenity doesn't provide much protection against vertebral fractures which makes me wonder if taking the drug is worth the risk of the side effects. (I am in the U.S.).

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Replies to "I am also curious about the quality of the bone produced by Evenity, for two reasons:..."

I appreciate you sharing this. These are the questions I have and not able to find any answers.

daisy17, do you remember where you read that Evenity doesn't provide much protection against fracture. Outside of the other cautions, I'm wondering about the bone--the quality of the bone. My understanding is that it is modeled bone rather than remodeled. Meaning that it doesn't allow for clearing away old bone, simply lays down new bone on top of the old. Sort of like replastering or repainting your house without removing the broken, damaged material underneath. In cartoons showing the bone laid down, there isn't any articulation. It is just solid bone. And easy to see why bone mineral density would be increased without reduction of fracture risk. I don't know, but it makes me wonder.

I am not sure if this addresses your question exactly but it is my understanding that : Postmenopausal women experience a shift in bone remodeling, with bone removal (resorption) outpacing bone building (formation) due to the significant drop in estrogen levels following menopause. So after you stop the Evenity your bones are not forming bone as usual before menopause (the bones are experiencing removal of bone) so I think that is why you need another drug to lock in the gains (or prevent his breaking down).

I have read different things on the internet about protection against vertebral fractures. It appears it does protect somewhat but has to be followed up with other drugs.

I would say that whether the drug is worth the risk of side effects would depend on your particular situation. For me it was as I felt it was the best treatment for me right now. I have taken 2 injections without any side effects, age 71, T score was -3.7. I am still considering what I will use after I finish the 12 month course of Evenity.