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← Return to Prolia for Osteoporosis
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"We found that delayed denosumab dosing, even short-term delay of 30 to 90 days, was significantly associated with an increased risk of incident fracture for all clinical fractures as well as vertebral fractures in the following 6-month period. In addition, as the dosing time was further delayed, the risk increased even more. There did not appear to be a substantial influence on fracture risk if the administration was delayed within 30 days of the previous injection. This study further confirms that the timing of subsequent injection is critical in the management of osteoporosis for those treated with denosumab."
https://www.e-enm.org/journal/view.php?number=2552#:~:text=Increased%20risks%20of%20fractures%20with,consistently%20observed%20for%20vertebral%20fractures.&text=Delayed%20denosumab%20dosing%2C%20even%20by,be%20emphasized%20when%20starting%20denosumab.
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I have experienced positive gains with no side effects using Prolia for 5 years. I WISH I had read the study mentioned by Gently before I took a 3-month “holiday” to have a dental implant. My rheumatologist didn’t offer information to help me with decision-making beforehand, she said “I was between a rock and a hard spot”. The 3rd month post dental work I experienced an L-1 acute fracture and L-3 sub acute.
I am moving through mental, emotional and physical implications of fractures wondering what to do next…I had a Prolia injection right after fractures occurred and am now in PT, doing well. My recent DEXA still shows gains.
If anyone has transitioned from Prolia post 5 years of using I would appreciate hearing about your experiences transitioning off of Prolia and or research regarding dental work timing when on Prolia. I’d like to share the information with my Periodontist and Rheumatologist and possibly help others facing this decision.