Hi, so sorry I missed seeing this timely!
At my endocrinologist recommendation, I take Tymlos at bedtime. I have a history of low blood pressure so that sounded best to me to avoid a fall. I have had no concerns since I started.
I most always stay hydrated throughout the day, often using an electrolyte in the afternoon/evening. I wouldn’t want to use it too close to bedtime to avoid having to get up to urinate.
I have experienced almost no side effects and I started with the full dose.
Maybe heart palpitations very briefly on one or two occasions since I began in late January of this year.
I hope things go well for you. I initially didn’t think I could do this but it has been easy. I’m wishing you stronger bones with the help of Tymlos and this site.

I take the Tymlos right before bedtime. A mild headache, sometimes, heart palpitations but both disappear quickly, no problem sleeping.