I wish I had insight to offer all you good people who are suffering so much! I hope you receive the effective help you need and deserve! I also have a question: I'm almost 68 and am in the midst of an MS attack (a new lesion at C2) -- this untimely event arriving long since everyone, including myself, assumed my disease to have moved into the secondary progressive stage. On Sunday I finished a three-day course of high-dose prednisone, 1350 mg per day. My neurologist insists that that current research indicates that there is no advantage to a taper dose and has refused to provide one. I am very concerned, as I do remember from many years ago that the one time I was not given a taper dose I had a very difficult experience (although after so many years I don't actually remember what it was like!). Do any of you folks have any insight about the importance/unimportance of a taper dose after short-term, high-dose prednisone for an MS attack? Thank you so much!