@susanjohnston it seems that it's totally a matter of personal preference as the when you do the tymlos injection. My nurse advised evenings in case it made me lightheaded (it did, momentarily) or sick in some other way which would interfere with my daytime activities. So I started doing it shortly after dinner, with 6 to 8 oz of water depending on how much I drank at dinner. And that works for me. If I have any lightheadedness I'll sit on the couch for a few minutes till it passes. Some people advise eating or drinking something salty before you inject, to raise the BP a bit and reduce the chance of lightheadedness or dizziness; I tried that and found it didn't really make a difference, but for some it does.

Some days I think about doing the shot in the morning, just to have it out of the way; lots of people seem to do that with no ill effects...