I think that is very smart to value how your heart will do on these drugs, especially if you're low risk for recurrence, because I don't notice the BC docs take that into consideration much. If a person is older, is already on several blood pressure meds ( I am on 3 types), we have to be wary of going on IA's even though that's considered a first line of defense. Glad I'm going to see a doc in Cardio-Oncology (should have been recommended earlier!) so she can watch what they're doing from a CVD point of view. BC doc is now are recommending I go on Fulvestrant shots instead. I did a lot of research on that med yesterday, and it works in a different way than AI's to block hormones, it's considered a SERD. It's new though, and who knows? I want more testing as we go along on my heart. What I found out is that AI's work by reducing the estrogen available to tumor cells; Fulvestrant works by blocking estrogen from binding to cancer cells. I can provide links to studies/reports if anyone wants to read them. For bones, I'm sticking with extra calcium & D in pills & diet, & more weight-bearing exercises. Zometa will just have to wait.