I was on Cymbalta 60 mg each night for 26 years after being diagnosed with Fibromyalgia, Chronic Fatigue and Coxsacki B enterovirus. I went off the Cymbalta several times during that time thinking it wasn't working for me but each time I went off my pain jumped by triple. I have had 6 spinal surgeries and still have bone spurs and herniated disks in my spine so I am in pain all the time. I went off the Cymbalta again about 2 years ago on my doctor's advice and since being off of it I have had no heartburn (which I suffered with for all those 26 years and had to take Nexium for). I am in more pain than I was in when taking the Cymbalta but at least I am now off of two medications. I was also taking 600 mg of Gabapentin every night for the pain and now I am down to 300 mg. I am living with the pain and it isn't fun but there are only so many medications one can take and they all have side effects. If one can get off of all but essential medications like thyroid, diabetes, heart etc. you will be better off.