Cribriform cancer . Newly diagnosed.

For unfavorable intermediate- to high-risk prostate cancer with cribriform features, the most effective treatment combines:

External Beam Radiation Therapy (EBRT)
Brachytherapy (Boost)
Androgen Deprivation Therapy (ADT)
Possible Addition of Androgen Receptor Inhibitor (ARi) like Darolutamide
I was discouraged from surgery due to the inevitability of salvage radiation therapy given cribriform, and the usually-associated perineural invasion

Don't let cribform scare you into thinking it's never cured because it is. I too was recently diagnosed with 4+ 3 gleason 7 with cribform pattern, 55 years old... 2 of 15 biopsie cores positive. Psa 4.63..cribform is curable was my main reason for commenting.

@rstamps Welcome and thank you for sharing your positive outcome with all of us! If you would be willing to add more detail about your age, the year you were diagnosed as well as the method(s) of treatment, it would be helpful to others who are struggling with a cribform diagnosis of their own. Best wishes to you!

Yes, absolutely curable! The fact that it is more “resistant” to radiation simply means you have to augment the treatment with a boost (HDRB) and ADT.
It is the same thinking that goes into treating a Gleason 8 or 9 - they are more aggressive (resistant) so they, in turn, are treated more aggressively.