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DiscussionTips on minimizing withdrawal symptoms from Effexor (aka Venlafaxine)
Depression & Anxiety | Last Active: 16 hours ago | Replies (6411)Comment receiving replies
Replies to "@secretwhitepop @bd1323 while it might be tempting to reinstate or to introduce another medication, give some..."
Hi Sandi, Thanks for the thoughtful response, and I wholeheartedly agree - SSRIs and SNRIs for anxiety seem to me to be a bad choice, as a professional specializing in risk analysis for medical devices, I am kicking myself for not further researching these drugs prior to taking them. - I researched the potential side effects, but the withdrawal/dependency aspects were all downplayed and I didn't specifically look at that side. Having now done so - I would be extremely reluctant to try this route again. For first world countries we are in a unique situation in that drug approval and marketing does not require a risk/benefit analysis vs. other existing treatments, solely a safety and efficacy analysis (in addition we are the only country that allows direct to consumer advertising). A compilation of studies done of Venlafaxine and other SS/SNRIs (references were included but the site won't allow me to post URLs, google for the NIHs pubmed database article PMC1681629 and PMC6097846) show Hedges scores for efficacy vs. placebo in the low to mid 30% range in patients with GAD without MDD, this corresponds to a Probability of Benefit of only about 13% and the NNT score (number needed to treat for one positive outcome) is 12. Given the significant side effects of these drugs not only during withdrawal but when taking them and the low probability of improvement I am surprised that these drugs are often the first course of action. However with aggressive marketing, misleading claims, and heavy industry influence in national physicians groups I shouldn't be (google venlafaxine FDA warning letter). Best of luck to you and and everyone else on this forum!
Thanks. Yeah, since it’s only been since February, and since I am able to cope better when not in certain environments, as always, I try and stick it out just one more day. Everyday. And when I have those glimpses of happiness, I revel in them.