Prostate Cancer
I'm 75 yrs old. PSA has risen over last few yrs. Rectal exam seemed ok. I had a blood test- 4K SCORE (OPKO) (LMW) that resulted with a 3.83 PSA(4.1 a month earlier). Results of the 4K score was 13.5, showing a "Intermediate Probability" of 19.7% of finding aggressive cancer upon a biopsy test. I request a MRI in 3 weeks. Great doctor and not worried but I'm new at this but born a worrier unfortunately. Thoughts please. Thanks
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The MRI is definitely the next step. The 4KScore Test is not all that accurate, 55% according to the attached list. The MRI is definitely the next best step. I am Including a list of different tests and how accurate they are. I don’t know if you’ve noticed that what has been recommended by people in this forum is the PSE test which is 93% accurate according to the below list.
The PSE test is designed to tell whether or not there is actually cancer in your bloodstream. If not, then you don’t need a biopsy. Did the 4KScore test also determine that?
The fact that your PSA went down could mean you have BPH, do you have any of the symptoms of that?
As early as you are collecting more information, and having testing done, you really don’t need to worry about treatment. There are so many different types of treatments you will live many years/decades if you actually are catching it this early.
Patrick Walsh MD's book Surviving Prostate Cancer and the free Patient Guide by the Prostate Cancer Foundation pcf.org available by download or in hard copy are good initial reference sources.
Best wishes.
I agree with @jeffmarc to try the PSE test which is 94+% accurate as it looks at a number of biomarkers in your body to determine the likelihood of prostate cancer. It is fairly new so your doctors may or may not believe in it but it is worth, insisting on getting it.
My PSA went up and down for 6 years. I had an enlarged prostate and two different urologists attributed it to the enlargement. My first MRI and biopsy in 2016 were negative. My next MRI in 2022 was also negative, but we decided on a 2nd biopsy which showed 2 cores of cancer. My point is to make sure you and your doctor feel comfortable with your decisions. Good luck.
Thank you
Just a follow up - PSA tests can vary over time my first PSA test was in January 2024 and it came back at 10.9 . I had a follow up test 6 weeks later and it came back at 11.0 . I had another test done in August 2024 and it came back at 8.6 . The urologist checked and after a 3T MRI they concluded that I don't have BPH . I am trying to avoid a biopsy as long as possible ( for several reasons ) I would prefer to get a PSE test instead at this time but I don't think my Health insurance company ( Kaiser - California ) will approve - I had to fight tooth and nail to even get an MRI . Biopsy's are more profitable for health care providers than MRI's ( or should I say much less costly ) . It's the same story with PSE tests - I know they are expensive and I'm sure that the doctors with lower or mid tier providers are under strict guidelines to follow the corporate mandates to avoid the more expensive procedures .
Top tier providers ( such as the Mayo clinic ) seem to be willing to approve tests and procedures that are the most logical and beneficial for the patient - regardless of the costs . Too bad the general public don't all have access to the top facilities - the current system is set up so even if a patient pays out of pocket they are not able to access certain procedures without being approved by their provider .
I learned about Dr Walsh's book through this support group. I ordered and my copy arrived this past Friday. Copyright 2023 -- as current as it can be.
Info from Amazon.
Thx
@vircet I understand edition 5 is the latest , although it is out of date . For example no mention of NanoKnife which is performed worldwide .