These are very good points, thank you. Yet even the best studies cannot take into consideration all the vulnerabilites of the population. So we must be as careful as posssilbe if we have vulnerabilites. and realize we each will expereicne the meds according to our vulnerabilites.
I was on tymlos ( pth) and expereeinced severe stomach pain/digestive issues. 8% of patients get this but few docs say anything about it. I went to a ayurvedic doctor for assessement. Ayurveda veiws digestion through the lens of liver, gallbladder and pancreas. After a few scary months ( I almost could not eat) I learned that PTH hormone receptors are everywhere - everywhere - in the body. FInally we uncovered that PTH receptors fill the pancreatic islands and mine where believed to be blocked with constant PTH - so the pancreatic enzymes needed for digestion could not get to the stomach. The fix was simple. I added pancreatic enzymes everyday before I ate and voila - I was able to manage the medication. These are things unque to my situation but an example of how studies just cannot cover everything. I hope my pancreae will returnn to normal now that I am off the medicine but I assume it will take time to detox.

Sclerostins research is based on a group of people who had a genetic mutation that effected sclerostin and that mutation gave them very thick bones. These people, to my limited understanding, were otherwise healthy though may be their incidnece of other specific diseases they carried that has not been studied. At least we know there are people naturally living with this condition. I dont have answers but I do hope we all take control of our care as best we can to make the best possible decsions.