Great info, jeffmarc; I asked about the PATCH trial because my friend has non alcoholic liver cirrhosis but needs ADT. His drs are concerned that Orgovyx could really damage his liver further.
However, the estradiol in the patch is absorbed initially thru the skin and doesn’t do what is called a “first pass” through the liver, thus sparing the enzyme flares that are so common.
And Kevin, I am sure his RO is gonna also give him “the look” when he mentions it!😳