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Cribriform cancer . Newly diagnosed.

Prostate Cancer | Last Active: 19 hours ago | Replies (24)
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@sicescu2

Everything I have read said that cribriform cancer is resistant to radiation. And once you have radiation, surgery is off the table. Hormone therapy? I have a great fear of no longer being able to exercise and I have a fear of losing muscle mass. I also like the psychological plus of being cancer free after surgery. I have been healthy, fit and fear the effects of all treatments but nothing scares me like hormone therapy.

Thanks for your input.

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Replies to "Everything I have read said that cribriform cancer is resistant to radiation. And once you have..."
jcf58 | @jcf58 | 2 days ago

I also had cribriform with my Gleason 7 (4+3). Mayo told me I was still an ideal candidate for TULSA Pro. I was 65 last July when treated. I know there are not long term results on Focal therapies yet but the 30 month data looks just as good as the other treatments with far better side effect results. The fact that all other treatments are still available to me if the cancer returns made TULSA a great choice for me.

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hanscasteels | @hanscasteels | 1 day ago

Are you sure of this?

I was working under the following assumptions:
1. Cribriform tumors have increased resistance to radiation (especially HDR brachytherapy alone).
2. Combination therapy (HDR + EBRT + ADT) is the best approach for controlling the disease.
3. Dose-escalated EBRT (>78 Gy) improves local control.
4. Darolutamide and/or Firmagon may help enhance radiation response.
5. Longer ADT duration (6-12 months) is beneficial. I am on an 18 month regimen

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