As for ADT, it's magic. Combined with radiation, surgery, and a 2nd gen ARSI (one of the so-called "-lutamides"), it has kept me in that remission for 3½ years, and I'll likely be on ADT and an ARSI for life.

The side-effects aren't great, but compared to what metastatic cancer can do to your husband, they're really not much to worry about. Over time, most of them have become more mild for me. Even sex is still possible on ADT (lots of info here in the forum), and other side-effects can get milder with simple mitigations like regular exercise, reducing alcohol consumption, a fan in the bedroom (for night sweats), etc.