I did this combo starting over a year ago and am still taking the pemetrexed every three weeks. My stomach bothers me occasionally but not bad, not enough to affect my eating. It does make me a little tired and can take a while to get going on something, but usually when I get moving and start moving enough that kind of goes away. It doesn't seem to be as bad as some of the other chemo regiments out there. I do have high liver enzymes which could be the pemetrexed or Tagrisso my doctor tells me, but I think this is not a common side effect.