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Switching from Lupron to Orgovyx.

Prostate Cancer | Last Active: Mar 10 11:10am | Replies (28)
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@kujhawk1978

The Lupron shot you've had will take some time after its advertised shelf life to clear your system.

I personally don't see any issue in switching, what does your medical team say?

As to mono-therapy with an ARI, yes, that is a possible option. Supporting data for that comes out of the EMBARK trial so discuss that with your medical team.

I'm off treatment now. When, not if, I go back treatment I intend to have that discussion with my oncologist. It should be interesting as he swears we'll do 24 months ADT + ARI and SBRT (the EMBARK trial has as an arm the 24 month ADT+ARI).

I also will discuss the PATCH trial which uses an trans-dermal estrogen patch vice ADT.

As to being on bone strengthening agents while on ADT, yes and no. My general understanding is one should have a baseline bone density scan. For those on longer term ADT, possibly, short term, less so. There is also resistance training which can be a factor in mitigating the bone density impacts of longer term ADT.

Kevin

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Replies to "The Lupron shot you've had will take some time after its advertised shelf life to clear..."
heavyphil | @heavyphil | Mar 8 4:34pm

Hi Kevin, I’ve read a bit about the PATCH trial and it seems like a real game changer for testosterone suppression without most of the nasty side effects associated with the usual ADT agents.
But they do emphasize that this trial is for non-metastatic cases. If I am reading your graphs correctly, it seems that you had some metastasis to lymph nodes; can you still use the trans-dermal patch?? And if not, why not? They neglect to mention that! Thanks for all your input snd info on this board.
Phil

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