Connect
← Return to Evenity and Cardio Warning? how significant?
Discussion
Evenity and Cardio Warning? how significant?
Osteoporosis & Bone Health | Last Active: Mar 11 8:50am | Replies (17)Comment receiving replies
I have had no heart issues, a relatively good cardiac calcium score, no diabetes, high blood pressure, stable bronchiectisis. I had a terrible reaction to Evenity. The target in Evenity is Sclerostin. That protein is present in my lungs. I suspect, but can not prove that my reaction was because of the effect of Evenity on my lungs. If one has a bad heart, I'd expect that any lung damage would cause more heart problems. Please see attached for scholarly articles.
Replies to "I have had no heart issues, a relatively good cardiac calcium score, no diabetes, high blood..."
hmb72,
sclerostin's activity in the body has been largely unstudied. Since Evenity works by blocking sclerostin, I wish that more studies had been done before the medication was approved. As it is Evenity is a real-world trial, without financial compensation for the participants. Because it is an uncontrolled trial, the results may not become apparent for ten to twenty years.
Evenity may turn out to be a wonder medication lessening the incidence of incidence of insulin resistance, controlling fat deposition.
But Evenity's manufacturer, Amgen, also brought us Prolia.
I wish that you hadn't been a part of this experiment And hope that restoring sclerostin to your lungs will heal them.
https://pubmed.ncbi.nlm.nih.gov/35963832/
Thank you for your post.
You said you took Evenity for two months but quit due to lung problems. Can you explain the symptoms you had and how soon they started after your first dose? Do you now have permanent lung damage? I am curious what your doctors had to say about this and if this is side effect is mentioned in the Amgen literature? My dr is suggesting Evenity but your experience and that of others is making me very anxious about taking Evenity. Also did you report this to the FDA? Thank you.
Connect
Thank you for the sholarly articles and taking the time to respond. I am so sorry that you unfortuantley expereinced a severe reaction. This must be scary. Medications effect many different areas of the body - and we are each so different in our vulnerabilities. I send postive energy that you can restore a stable balance in the lungs and find a medication that can help your bones. I dont find any meds that are without issues.... I spent 2 years on tymlos only to find that my foot bones have worsened. TYmlos/Forteo can weaken cortical bone. I struggled with bilateral foot stress fractures for many months. Tymlos had serious side effects for me - heart palpations and stomach pain. I pray that we each find what is best for our bodies with the least harm. Be postive and look for the light.