I have been taking Duloxetine for about 5 years for neuropathy in my toes (60 mg once a day). It did take away the electric shocks I was feeling and definitely helped my fibromyalgia, too. Side effects are dizziness. I also take 50 mg of pregablin twice a day to help the neuropathy pain. They work together with dizziness being the worse side effect. Also weight gain is common. I still have bad pain spikes, particularly at night, but my pain is not constant and really hasn't progressed beyond my toes. I used to live with ice packs before I got on these 2 meds. So they definitely help.