Anniesan Regarding "excruciating muscle spasms, esp in upper thighs and feet" ,I could have written this.! I had to jump out of bed last night and stand for 5 minutes to try to get the pain to stop. It was excruciating. I didn't know if that was bone pain from the tymols or what. I'm in my 9th month of Tymlos and had an extremely high P1NP level (715) and don't get another draw until May.