@dwyermw
I assume your urologist is ordering more biopsies. With a 3+3=6 what I read is mostly surveilance.

You did not mentioned what your PSA was and how much climbing. That is what I assume is why your urologist wants more biopsies. When doing biopsies very hard to get every cell of prostate. So they usually do a lot but can miss areas or cells. So even with the 3+3 and then you get rising PSA is of concern.

The rise of PSA could be BPH or cancer.

When I had my proton radiation at UFHPTI I asked if going to radiate the biopsy areas or the whole prostate. My R/O says I radiate the entire prostate and margine to ensure we get all areas treated. He said very easy to miss an area that has cancer cells but were not biopsied. We are talking about alot of diagnosis at celluar level that there are no tumors.

Good idea to asked this question to your urologist. If in doubt you can always get a second opinion. If this was me and PSA still rising but had a 3+3=6 (mine was 3+4=7) I would see why my urologist wanted to go back in and take more biopsies.