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Bone density drugs

Bones, Joints & Muscles | Last Active: 6 days ago | Replies (115)

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@gently

bayhorse,
It is the same type of problem. Evenity to a lesser degree. Prolia to a greater degree. Both Prolia and Evenity also create new bone on the outside of your bone work creating as sort of thick scaffold. It looks great on dxa increasing BMD, but it is more brittle bone.
In reading patient experiences, I've noticed that individuals with autoimmune disease have more side effects with bisphosphonates. Osteoclasts, the suppression target of antiresorptive medication, are part of the immune system. The effects seem to depend upon the type of autoimmune disease the patient has.
Worse than just increasing the susceptibility to adverse effect is that some diseases are advanced by the use of antiresorptives. Some though are advantageously repressed by the use of bisphosponates Rheumatoid Arthritis is repressed. There is a new article on SLE indicating that it can be activated by the use of bisphosphonates. There is a concern about mast cells, but I haven't seen anything convincing.
I'm glad that you are looking at this with concern for your vulnerabilities. I didn't want to post a discouraging number of links so have a second comment that you can ignore or explore.
Remember that I am not a medical person and have no personal experience with bisphosphonates. You really have to question anything you read, even when its PubMed.

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Replies to "bayhorse, It is the same type of problem. Evenity to a lesser degree. Prolia to a..."

@gently, thanks once again for the information, and for your quick response. No worries that I will consider you a medical expert; I understand you are not. But you do have a great knack for research, and for explaining the research, and I truly value that and am grateful for it.

I do have lupus, so am especially grateful you let me know that there's now some indication that the bisphosphinates can activate SLE. Mine is mostly controlled with drugs, as is my ulcerative colitis. (My third autoimmune gift, celiac disease, I manage with an extremely strict gluten-free diet, and even then have some issues.) I also seem to have mast cell/histamine production issues. I have had to deal with these illnesses for the past 40+ years, and if any of them were to be exacerbated by an osteoporosis drug, I would be angry indeed.

If you would like, feel free to list any number of "discouraging links" that might pertain to the autoimmune/op drug issue. As far as I'm concerned, forewarned is forearmed. And I certainly will need my questions and evidence lined up solidly when I next meet with my endo.

Meantime, thanks again. I wish you all the best!