← Return to PSA 8.6, MRI PIRADS 5, Biopsy scheduled, so a bit worried

Discussion
Comment receiving replies
@handera

Thanks for clarifying.

PI-RADS 3 means the findings are neither clearly benign nor obviously malignant (equivocal).

Also, the lack of focal lesions and a well-defined capsule makes a diffuse malignancy less likely. Prostatitis (inflammation) or other non-cancerous conditions could also explain these findings. I’d recommend watching Dr. Mark Emberton’s presentation on “MRI-invisible lesions and low risk prostate cancer”…it was incredibly useful for me.


Your prostate volume (95 mL) is significantly enlarged (normal is ~20–30 mL), which could be due to benign prostatic hyperplasia (BPH). Larger prostates can elevate PSA due to increased tissue volume rather than cancer.

One thing I learned when studying the effects of exercise on slowing PCa progression is that weight reduction can also cause PSA to decrease. Therefore, you might want to have your PSA retested, if you have not already done so since losing 20 lbs.

Finally, I found that by inputting all my test data (including my MRI report), as provided in its original form, into Grok3, I was able to get a layman’s explanation of its meaning which was quite useful in explaining things that were confusing to me. It’s not a substitute for your doctor, but it can help clarify obtuse medical language and seemingly conflicting test results and statements.

All the best,

Alan

Jump to this post


Replies to "Thanks for clarifying. PI-RADS 3 means the findings are neither clearly benign nor obviously malignant (equivocal)...."

Appreciate that. I will definitely watch the presentation.
I lost my 20lbs after my high PSA tests and a complete change in my diet. I also stopped drinking beer and wine. I think I’ve had an enlarged prostate for some time. What is Grok3? And I think I’ll ask my doctor to order another PSA before the 6 month MRI. It might still be elevated due to my enlarged prostate but if it’s not increasing it will give me some peace of mind. I never enjoyed running when I was younger, not sure if I do now, but it feels sort of empowering and satisfying.