1. < Prostate Cancer

Switching from Lupron to Orgovyx.

Posted by chippydoo @chippydoo, 3 days ago

Doing 6 months ADT and considering switching from Lupron to Orgovyx for my second 3-month period. Have any of you done this? If so, I would be interested in hearing about your experience.

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round5 | @round5 | 12 hours ago
In reply to @laccoameno5 "So how is Nubequa different than Orgovyx? I too am having huge problems wth the SE's..." + (show)
@laccoameno5

So how is Nubequa different than Orgovyx? I too am having huge problems wth the SE's of Lupron as well as Abiraterone and Prednisone which were added with my last shot 11/2025 of Lupron. Next Lupron shot was to be 2/2025. I declined due to horrible SE's Meeting with main oncologist 4/1/2025 to discuss options. More info about Nubeqa please. On the web it states it is often used in combo with chemo therapy. Is this so in your case?
Thanks,
SW

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You are correct in my case. I qualified for Neubeqa As an add-on to Lupron and Docetaxel
which is the triplet therapy (and I also received Carboplatin). All this was followed by Pluvicto. I know Lupron is in the gonadotropin-releasing hormone (GnRH) analogue family of medications. It works by decreasing gonadotropins and therefore decreasing testosterone and estradiol and I think Orgovyx is too,it just won’t linger in the bloodstream like the injections do. Nubeqa is an Androgen receptor pathway inhibitor. It is my hope/prayer that I can regain a normal level of testosterone in my bloodstream for the other normal functions of my body and that the Nubeqa will still block the testosterone at the cancer receptor site. I hope that all makes sense.

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chippydoo | @chippydoo | 11 hours ago

I can sure understand your hopes a prayer on that one. Something I am going to add to my talking points book for my future treatments.

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jeffMar | @jeffmarc | 11 hours ago
In reply to @krs03 "RE: All ADT 'users' There is research saying a better target is to keep testosterone below..." + (show)
@krs03

RE: All ADT 'users'
There is research saying a better target is to keep testosterone below 20.
I am going to request a baseline DEXA, bone density scan, during my time as Lupron wears off, prior to starting an oral ADT. Is this a concern of many? BTW, the 12-week Lupron Depot shot is still giving me hot flashes at week 28.
(RP 14 weeks after Lupron, no T results yet, PSA < 0.02)

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That below 20 issue is exactly what I contacted my oncologist about. My testosterone has slowly Creeped up to 25 from below five. It’s a pretty fast doubling rate for 8 months. You would think that after seven years of Lupron, it would not start rising so quickly. I did take Orgovyx the last eight months, but that’s still a pretty quick rise.

The thing is, even though I stopped it the hot flashes are as annoying as ever.

Are you on bone strengtheners now? If you are on ADT is it highly recommended that you take bone Strengtheners like Fosamax, Zometa or Xgeva. Was in a webinar a few months ago, where a doctor who specializes in bone conditions was really emphatic about the need to do this.

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2 replies
chippydoo | @chippydoo | 11 hours ago
In reply to @jeffmarc "I know a lot of people over at Ancan.org Who have switched to just Nubeqa And..." + (show)
@jeffmarc

I know a lot of people over at Ancan.org Who have switched to just Nubeqa And are having no PSA issues for most of them. I quit taking Orgovyx Because I had been on at eight years and it is very unlikely that my testosterone will come back Since I was on Lupron for seven of those years.

For me quitting Orgovyx Was not a big deal, But I have to keep an eye on my testosterone. If it comes back, I will need to restart Orgovyx.

If you have had undetectable PSA for quite a few months Then dropping the ADT could work for you. Make sure to test your testosterone regularly, If it gets above 50, you need to get on an ADT Drug according to my oncologist.

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I am a third of the way through my first 6-month ADT cycle with 25 sessions of salvage radiation. At this point I presume "we" don't know where I stand in regard to long term treatment.

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1 reply
jeffMar | @jeffmarc | 10 hours ago
In reply to @chippydoo "I am a third of the way through my first 6-month ADT cycle with 25 sessions..." + (show)
@chippydoo

I am a third of the way through my first 6-month ADT cycle with 25 sessions of salvage radiation. At this point I presume "we" don't know where I stand in regard to long term treatment.

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Everybody is so differentthere’s just no way to know what your future is.

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chippydoo | @chippydoo | 9 hours ago
In reply to @jeffmarc "That below 20 issue is exactly what I contacted my oncologist about. My testosterone has slowly..." + (show)
@jeffmarc

That below 20 issue is exactly what I contacted my oncologist about. My testosterone has slowly Creeped up to 25 from below five. It’s a pretty fast doubling rate for 8 months. You would think that after seven years of Lupron, it would not start rising so quickly. I did take Orgovyx the last eight months, but that’s still a pretty quick rise.

The thing is, even though I stopped it the hot flashes are as annoying as ever.

Are you on bone strengtheners now? If you are on ADT is it highly recommended that you take bone Strengtheners like Fosamax, Zometa or Xgeva. Was in a webinar a few months ago, where a doctor who specializes in bone conditions was really emphatic about the need to do this.

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No, I'm not on bone meds. At this time my doctor considers me a short timer on ADT until we find out otherwise. This is my first round.`I also weight train and mountain bike which helps bang the bones for bone strength. I'll probably get there eventually.

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krs03 | @krs03 | 8 hours ago
In reply to @jeffmarc "That below 20 issue is exactly what I contacted my oncologist about. My testosterone has slowly..." + (show)
@jeffmarc

That below 20 issue is exactly what I contacted my oncologist about. My testosterone has slowly Creeped up to 25 from below five. It’s a pretty fast doubling rate for 8 months. You would think that after seven years of Lupron, it would not start rising so quickly. I did take Orgovyx the last eight months, but that’s still a pretty quick rise.

The thing is, even though I stopped it the hot flashes are as annoying as ever.

Are you on bone strengtheners now? If you are on ADT is it highly recommended that you take bone Strengtheners like Fosamax, Zometa or Xgeva. Was in a webinar a few months ago, where a doctor who specializes in bone conditions was really emphatic about the need to do this.

Jump to this post

Also not on any bone strengtheners. Just now getting into the ADT regimen and not sure if it will continue or let the Lupron die off to see where my T and PSA are at that point. I'm now just saying no to Lupron and yes to an oral medication if I need to go back on an ADT. Getting advice soon from an oncologist.
But, as mentioned, I'd like to have a bone density check first, for a baseline.

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