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PSA Nadir main deciding factor when one can start on Intermittent ADT?

Prostate Cancer | Last Active: Mar 5 4:19pm | Replies (26)
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@ajpernsteiner

I was gleason 10. I had 45 Radiation and 18 months Orgovyx. My Dr had initially wanted 24 months. My PSA had dropped to .04 at the end of radiation, and stayed there for the next 12 months . At 18 months on Orgovyx it was decided to try a holiday, that was March of 2024. By September my psa had gone to 1.5, by Oct 24 to 2.5. I went back on Orgovyx and had a PSMA scan. It showed lesions on my spine, rib, femur. I am now on Orleada and Orgovyx. Just finished cyberknife on my rib and spine, still have the radiation coming up on my arm. Not sure if a longer stay on Orgovyx would have changed anything, but what I have now is a much bigger struggle than just being on Orgovyx.

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Replies to "I was gleason 10. I had 45 Radiation and 18 months Orgovyx. My Dr had initially..."
ava11 | @ava11 | Mar 3 10:52am

I am so sorry you had such a bad outcome. For 12 months on Orgovyx did not bring down PSA from 0.04? Does it mean ADT was not helping you or 0.04 is your Nadir? What was your Testosterone level after 12 months on Orgovyx?
JeffMar was warning about stopping Orgovyx too soon and what could happen. But you didn't stop too soon.
Be positive. At least your Cancer didn't spread to any soft tissue. I understand radiation is effective killing cancer cells in the bone.
Prayers to your health.

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jeffMar | @jeffmarc | Mar 3 11:33am

I know a few people that have stopped ADT, For a holiday, and within a six months to a year their cancer has come back with many metastasis.

Taking a holiday can be attractive, but it can also be dangerous. I personally would want monthly test for the first six months, But then with my having BRCA2 I really can’t stop taking the cancer drugs.

I know someone who manages an online webinar that has BRCA2 And he has gone on holiday twice. He now lights up the PSMA PET scan like a Christmas tree.

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ava11 | @ava11 | Mar 3 8:46pm

How many times you had PSMA pet scan before September 2024?

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