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Oxaliplatin is no walk in the park, advice for CAPOX regimen?

Colorectal Cancer | Last Active: 13 hours ago | Replies (35)
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@roywalton

I'd like to know more about your diagnosis.... For one thing 6 month FOLFOX is being used less and less, research is determining that 3 months is as effective and for many patients post surgery chemo has no improve survival, over no chemo at all. Secondly I think your experience is in the minority and I'd hate to think that patients will read this and be frightened. For example my 3 month chemo was really uneventful except for very slight neuropathy and I think one instance of diarrhea. Of course everyone's different!

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Replies to "I'd like to know more about your diagnosis.... For one thing 6 month FOLFOX is being..."
branckerd | @branckerd | Mar 3 7:56am

Yes everyone reacts differently I could not take My body couldn’t handle

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isadora2021 | @isadora2021 | Mar 4 4:05am

@roywalton Thank you for raising that. Food for thought 🤔

My oncologist and I chose to treat my stage 4 appendix cancer (which is treated the same way as CRC) with Folfiri not Folfox (plus Avastin) as first line in order to avoid oxaliplatin. I ended up not needing to go second line and reached NED without it.

I’m not sure why Folfox is used IF Folfiri is suitable. I didn’t want anything to do with oxaliplatin, if at all possible. I had no and still have no neuropathy (almost 3 years after treatment ended).
https://www.medsci.org/v15p0659.htm#:~:text=There%20is%20little%20difference%20in,1%2C9%2C10%5D.
I searched your comment about 3 months instead of 6 months fortnightly treatments and see this applies to adjuvant oxaliplatin. Very interesting. I’ll bear that in my mind if I need to go back into treatment!
https://pmc.ncbi.nlm.nih.gov/articles/PMC6936167/

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